FD & MAS - PHOSPHATE WASTING STUDIES
Renal Phosphate Wasting in Fibrous Dysplasia of Bone Is Part of a Generalized Renal Tubular Dysfunction Similar to That Seen in Tumor-Induced Osteomalacia, Journal of Bone and Mineral Research, Vol. 16, Number 5, 2001, Michael T. Collins, Caroline Chebli Janet Jones, Harvey Kushner, Mark Consugar, Piero Rinaldo, Shlomo WientroubPaolo Bianco,and Pamela Gehron Robey
This is a study of 42 patients with FD/MAS seen at the NIH. The investigators evaluated how phosphorus is controlled in patients with FD/MAS. They concluded that abnormal phosphorus metabolism is common (48%), and the likely cause is a circulating factor (hormone) made by the fibrous dysplastic bone. This has implications for the evaluation and treatment of FD/MAS patients, as low blood phosphorus is associated with worsening of FD.
FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting, The Journal of Clinical Investigation, Vol. 112, Number 3, September 2003, Mara Riminucci, Michael T. Collins, Neal S. Fedarko, Natasha Cherman, Alessandro Corsi, Kenneth E. White, Steven Waguespack, Anurag Gupta, Tamara Hannon,8 Michael J. Econs, Paolo Bianco, and Pamela Gehron Robey
This study identifies fibroblast growth factor –23 (FGF-23) as the factor (hormone) that is made by FD bone that causes the abnormalities in phosphorus metabolism that are associated with FD.